Full Idea
Empedocles used numerical ratios to explain different kinds of matter; for example, bone is two parts water, four parts fire, two parts earth; and blood is an equal blend of all four elements.
Gist of Idea
Empedocles says bone is water, fire and earth in ratio 2:4:2
Source
report of Empedocles (fragments/reports [c.453 BCE]) by Brad Inwood - Empedocles
Book Reference
'Encyclopedia of Classical Philosophy', ed/tr. Zeyl,Donald J. [Fitzroy Dearborn 1997], p.205
A Reaction
Why isn't the ration 1:2:1? This presumably shows the influence of Pythagoras (who had also been based in Italy, like Empedocles), as well as that of the earlier naturalistic philosophers. It was a very good theory, though wrong.